Circulating Skeletal Stem Cells
نویسندگان
چکیده
منابع مشابه
Circulating Skeletal Stem Cells
We report the isolation of adherent, clonogenic, fibroblast-like cells with osteogenic and adipogenic potential from the blood of four mammalian species. These cells phenotypically resemble but are distinguishable from skeletal stem cells found in bone marrow (stromal stem cells, "mesenchymal stem cells"). The osteogenic potential of the blood-borne cells was proven by an in vivo transplantatio...
متن کاملSkeletal muscle stem cells
Satellite cells are myogenic stem cells responsible for the post-natal growth, repair and maintenance of skeletal muscle. This review focuses on the basic biology of the satellite cell with emphasis on its role in muscle repair and parallels between embryonic myogenesis and muscle regeneration. Recent advances have altered the long-standing view of the satellite cell as a committed myogenic ste...
متن کاملThe Role of Satellite Cells and Circulating Stem Cells in Regeneration of Skeletal Muscle
Repair and regeneration of skeletal muscle in the postnatal mammal has long been supposed to be primarily or entirely accomplished by the population of satellite cells that are sequestered between the plasma membane of the muscle fibre and its overlying basement membrane. However it has never been clear whether all satellite cells participate and whether only satellite cells participate in this...
متن کاملHuman circulating AC133(+) stem cells restore dystrophin expression and ameliorate function in dystrophic skeletal muscle.
Duchenne muscular dystrophy (DMD) is a common X-linked disease characterized by widespread muscle damage that invariably leads to paralysis and death. There is currently no therapy for this disease. Here we report that a subpopulation of circulating cells expressing AC133, a well-characterized marker of hematopoietic stem cells, also expresses early myogenic markers. Freshly isolated, circulati...
متن کاملRepairing skeletal muscle: regenerative potential of skeletal muscle stem cells.
Skeletal muscle damaged by injury or by degenerative diseases such as muscular dystrophy is able to regenerate new muscle fibers. Regeneration mainly depends upon satellite cells, myogenic progenitors localized between the basal lamina and the muscle fiber membrane. However, other cell types outside the basal lamina, such as pericytes, also have myogenic potency. Here, we discuss the main prope...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2001
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.153.5.1133